Astrocytes found to bridge gap between global brain activity and localized circuits

Published: May 14th, 2012

Category: Recent Relevant Publications

Global network activity in the brain modulates local neural circuitry via calcium signaling in non-neuronal cells called astrocytes according to research led by Hajime Hirase of the RIKEN Brain Science Institute. Using electrodes and and two-photon microscopy imaging, the authors show that signaling transforms cholinergic modulation to cortical plasticity in vivo. The finding clarifies the link between two important processes in the brain.

Takata, et al. Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J. Neurosci 31, 18155–18165